BimS, EL, L (AA 20-40) 抗体
This anti- antibody is a 大鼠 单克隆 antibody detecting in FACS, IP, IHC, WB, ICC 和 ELISA. Suitable for 小鼠, 犬, 人, 猴 和 大鼠.
Quick Overview for BimS, EL, L (AA 20-40) 抗体 (ABIN2745516)
抗原
BimS, EL, L
适用
小鼠, 犬, 人, 猴, 大鼠
宿主
大鼠
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), ELISA
克隆位点
3C5
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抗原表位
- AA 20-40
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特异性
- Recognizes an epitope within aa 20-40 of human, mouse, rat, monkey and dog BimL (~19 kDa), BimEL (~23 kDa), and BimS (~16 kDa). Also recognizes the six novel isoforms of human Bim, generated by alternative splicing and lacking the C-terminal hydrophobic region.
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交叉反应
- 犬, 人, 猴, 小鼠, 大鼠
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纯度
- >95 % (SDS-PAGE)
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内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
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免疫原
- Synthetic peptide corresponding to aa 20-40 of mouse BimL.
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 0.02 % sodium azide and 25 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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- BimS, EL, L
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别名
- BimS/EL/L
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背景
- Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.
抗原
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